Science

Risk of heart failure may increase with age due to Y

The Y chromosome, involved in sex determination, mysteriously disappears from some men’s immune cells as they get older – and that could be fatal

Health



14 July 2022

X and Y chromosome

The Y chromosome (right) is smaller than the X (left)

BIOPHOTO ASSOCIATES / SCIENCE PHOTO LIBRARY

The immune cells of many older men lose their Y chromosomes, and this may contribute to men having a higher rate of heart disease than women.

Health risks from Y chromosome loss have long been suspected, but evidence from animals and people now adds more support to the idea – and may suggest a treatment for the damage caused to the heart.

DNA is packaged into chromosomes, with the cells of most men and transgender women carrying one X and one Y, …


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